The Top Ten lists in Medicine feature papers published during the last two years (excluding review articles) that were most cited in current journal articles indexed by Thomson Scientific during a recent two-month period. Papers are ranked according to the latest bimonthly citation count. The articles below are accompanied by expert discussion and analysis (including comments from the papers’ authors) written by one of four veteran scientist-journalists and longtime ScienceWatch.com contributors.

March/April 2008

Investigating Angiogenesis Inhibitors and Other Drugs in Kidney Cancer
by David W. Sharp

A comparatively recent treatment for renal-cell carcinoma involves tyrosine-kinase-inhibiting agents, including sunitinib, bevacizumab, and temsirolimus, to block angiogenesis and tumor-cell proliferation. Studies suggest that, compared to interferon, these agents improved survival.
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