FAST BREAKING PAPERS
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Russel J. Reiter talks with
ScienceWatch.com and answers a few questions about
this month's Fast Breaking Paper in the field of Biology
& Biochemistry. The author has also sent along images
of their work.
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Field: Biology & Biochemistry
Article Title: One molecule, many derivatives: A
never-ending interaction of melatonin with reactive oxygen
and nitrogen species?
Authors: Tan, DX;Manchester, LC;Terron, MP;Flores,
LJ;Reiter
, RJ
Journal: J PINEAL RES
Volume: 42
Issue: 1
Page: 28-42
Year: JAN 2007
* Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct
Biol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
* Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct
Biol, San Antonio, TX 78229 USA.
(addresses may have been truncated; see full
article)
Return to interview.
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Figures and descriptions:
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Figure
1:
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Figure 1: The cascade of reactions by which
melatonin and its metabolites detoxify free
radicals and associated products, i.e.,
oxidants.
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Figure
2:
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Figure 2: During aging, endogenous
melatonin levels wane as illustrated. The
reduction in melatonin may be consequential
in exaggerating some age-related diseases.
Also, this figure illustrates the exclusive
nighttime production of melatonin.
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Figure
3:
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Figure 3: Damage to the brain is frequently
extensive after a stroke. This damage in
experimental animals can be markedly
attenuated by giving melatonin at the time
of or shortly after stroke induction (A).
The white (non-stained) area of the brain
is dead tissue. The amount reduction in
dead brain tissue as a result of melatonin
administration is shown in the graph on the
right (B).
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interview.
2008 : February 2008 - Fast Breaking Papers : Russel J. Reiter (Figures)
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