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Abstract: “To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and...

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[Authors' affiliations: 7 institutions worldwide]

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Abstract: “BACKGROUND Enzalutamide (formerly called MDV3100) targets multiple steps in the androgen-receptor-signaling pathway, the major driver of prostate-cancer growth. We aimed to evaluate...

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“Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010,” by K.M. Flegal, M.D. Carroll, B.K. Kit, C.L. Ogden., JAMA – Journal of the American Medical...

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Abstract:“We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase...

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“Intratumour heterogeneity and branched evolution revealed by multiregion sequencing,” by Marco Gerlinger, et al., New England Journal of Medicine, 366(10): 883-92, 8 March 2012.    

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Abstract: “BACKGROUND Abiraterone acetate, an androgen biosynthesis inhibitor, improves overall survival in patients with metastatic castration-resistant prostate cancer after...

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Abstract: “BACKGROUND Blockade of programmed death 1 (PD-1), an inhibitory receptor expressed by T cells, can overcome immune resistance. We assessed the antitumor activity and...

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Abstract: “IMPORTANCE More than one-third of adults and 17% of youth in the United States are obese, although the prevalence remained stable between 2003-2004 and 2009-2010...

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Abstract: “BACKGROUND Infection of poultry with influenza A subtype H7 viruses occurs worldwide, but the introduction of this subtype to humans in Asia has not been observed...

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Abstract: “The Large Underground Xenon (LUX) experiment is a dual-phase xenon time-projection chamber operating at the Sanford Underground Research Facility (Lead, South Dakota). The LUX...

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Abstract: “A search for the Standard Model Higgs boson in proton-proton collisions with the ATLAS detector at the LHC is presented. The datasets used correspond to integrated...

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