genetics

Weekly Byte

“An integrated encyclopedia of DNA elements in the human genome,” by the ENCODE Project Consortium, Nature, 489(7414): 57-74, 6 September 2012.

[Authors' affiliations: 85 institutions...

Weekly Byte

“An integrated map of genetic variation from 1,092 human genomes,” by the 1000 Genomes Project, Nature, 491(7422): 56-65, 1 November 2012.  

[Authors' affiliations: 115 institutions...

Weekly Byte

[Authors' affiliations: Broad Institute, Cambridge, MA; MIT, Cambridge, MA; Harvard University, Cambridge, MA, Tsinghua University, Beijing, China; Columbia University, New York, NY; Rockefeller...

Weekly Byte

Abstract: “The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has...

Weekly Byte

Abstract: “Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly...

Weekly Byte

[Authors' affiliations: 115 institutions worldwide]

Weekly Byte

Abstract: “Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short...

Weekly Byte

Abstract: “Context: Autism is considered the most heritable of neurodevelopmental disorders, mainly because of the large difference in concordance rates between monozygotic and...

In Five Disorders, Genetic Markers Belie DSM-5 Distinctions
Sci-Bytes

The new, fifth, edition of the psychiatric bible formally known as Diagnostic and Statistical Manual of Mental Disorders, henceforth DSM-5, went on sale on 22 May 2013, but even...

Gene Therapy Restores Eyesight
Sci-Bytes

Gene therapy—fix a genetic disease by giving the patient a working copy of the relevant gene—is in the news. Researchers in Oxford, UK and in Philadelphia, Pennsylvania, recently announced that...

Passive dilution of 5hmC during preimplantation development.
Sci-Bytes

It is (reasonably) common knowledge that DNA is written in a simple four-letter code: ACTG. Too simple, actually. A fifth base—5-methylcytosine 5mC—plays a crucial role in determining which bits...

Type 1 Diabetes is Preventable
Sci-Bytes

A versatile human genome engineering platform is a reality, paving the way for the modification of disease-causing genes and helping to prevent certain...

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