Hot Paper in Biology

March 2015
“Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease,” by Luke Jostins, et al., Nature, 491 (7422): 119-24, 1 November 2012.

Abstract: “Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations(1). Genome-wide association studies and subsequent meta-analyses of these two diseases(2,3) as separate phenotypes have implicated previously unsuspected mechanisms, such as autophagy(4), in their pathogenesis and showed that some IBD loci are shared with other inflammatory diseases(5). Here we expand on the knowledge of relevant pathways by undertaking a meta-analysis of Crohn's disease and ulcerative colitis genome-wide association scans, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls. We identify 71 new associations, for a total of 163 IBD loci, that meet genome-wide significance thresholds. Most loci contribute to both phenotypes, and both directional (consistently favouring one allele over the course of human history) and balancing (favouring the retention of both alleles within populations) selection effects are evident. Many IBD loci are also implicated in other immune-mediated disorders, most notably with ankylosing spondylitis and psoriasis. We also observe considerable overlap between susceptibility loci for IBD and mycobacterial infection. Gene co-expression network analysis emphasizes this relationship, with pathways shared between host responses to mycobacteria and those predisposing to IBD.”

 

This 2012 report from Nature was cited 54 times in current journal articles indexed by Thomson Reuters during September-October 2014. With that two-month total, the report currently ranks as the third-most-cited Biology paper published in the last two years, aside from reviews. Prior to the most recent bimonthly count, citations to the report have accrued as follows, as tracked by Essential Science Indicators Hot Papers:
 

July-August 2014: 46 citations
May-June 2014: 56
March-April 2014: 33
January-February 2014: 42
November-December 2013: 31
September-October 2013: 36
July-August 2013: 32
May-June 2013: 21
March-April 2013: 11
January-February 2013: 18
November-December 2012: 2

 

Total citations to date: 382

 

SOURCE: Thomson Reuters Web of Science

The data and citation records included in this report are from Thomson Reuters Web of ScienceTM. Web of ScienceTM is a registered trademark of Thomson Reuters. All rights reserved.