Hot Paper in Biology

June 2014

“An integrated encyclopedia of DNA elements in the human genome,” by the ENCODE Project Consortium, Nature, 489(7414): 57-74, 6 September 2012.

[Authors' affiliations: 85 institutions worldwide]

Abstract: “The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence variants linked to human disease, and can thereby guide interpretation of this variation. Overall, the project provides new insights into the organization and regulation of our genes and genome, and is an expansive resource of functional annotations for biomedical research.”

This 2012 report from Nature was cited 109 times in current journal articles indexed by Thomson Reuters during January-February 2014. For a sixth consecutive bimonthly period, this report ranks as the most-cited biology paper published in the last two years, aside from reviews. Prior to the most recent two-month tally, citations to the report have accrued as follows, as tracked by Essential Science Indicators Hot Papers:


November-December 2013: 116 citations
September-October: 124
July-August 2013: 124
May-June 2013: 96
March-April 2013: 99
January-February 2013: 109
November-December 2012: 28
September-October 2012: 5

Total citations to date: 810


The data and citation records included in this report are from Thomson Reuters Web of ScienceTM. Web of ScienceTM is a registered trademark of Thomson Reuters. All rights reserved.