Hot Paper in Medicine

September 2014
“Comprehensive molecular portraits of human breast tumours,” by the Cancer Genome Atlas Network, Nature, 490(7418): 61-70, 4 October 2012.

[Authors' affiliations: 95 institutions worldwide]

Abstract: “We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers; however, there were numerous subtype-associated and novel gene mutations including the enrichment of specific mutations in GATA3, PIK3CA and MAP3K1 with the luminal A subtype. We identified two novel protein-expression-defined subgroups, possibly produced by stromal/microenvironmental elements, and integrated analyses identified specific signalling pathways dominant in each molecular subtype including a HER2/phosphorylated HER2/EGFR/phosphorylated EGFR signature within the HER2-enriched expression subtype. Comparison of basal-like breast tumours with high-grade serous ovarian tumours showed many molecular commonalities, indicating a related aetiology and similar therapeutic opportunities. The biological finding of the four main breast cancer subtypes caused by different subsets of genetic and epigenetic abnormalities raises the hypothesis that much of the clinically observable plasticity and heterogeneity occurs within, and not across, these major biological subtypes of breast cancer.”


This 2012 report from Nature was cited 60 times in current journal articles indexed by Thomson Reuters during March-April 2014. Thanks to that two-month tally, this is currently the second-most-cited paper, aside from reviews, indexed in the last two years in the main field of Clinical Medicine. A report from the Cancer Genome Atlas Network, this work represents the international collaboration of nearly 400 authors. (A dozen or so of these scientists are highlighted in ScienceWatch’s latest annual collection of the year’s “hottest authors,” as described in the opening section of our report on the World’s Most Influential Scientific Minds, based on the recently re-launched Thomson Reuters website featuring a searchable database of roughly 3,000 Highly Cited Authors in each of 21 main fields.) Prior to the most recent bimonthly count, citations to the Nature report have accrued as follows, as tracked by Essential Science Indicators Hot Papers:


January-February 2014: 78 citations
November-December 2013: 71
September-October 2013: 97
July-August 2013: 56
May-June 2013: 48
March-April 2013: 30
January-February 2013: 63
November-December 2012: 10

Total citations to date: 513


SOURCE: Thomson Reuters Web of Science

The data and citation records included in this report are from Thomson Reuters Web of ScienceTM. Web of ScienceTM is a registered trademark of Thomson Reuters. All rights reserved.