Hot Paper in Medicine

October 2014
“Comprehensive molecular characterization of human colon and rectal cancer,” by the Cancer Genome Atlas Network, Nature, 490(7407): 330-7, 19 August 2012.

Abstract: “To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression. A subset of these samples (97) underwent low-depth-of-coverage whole-genome sequencing. In total, 16% of colorectal carcinomas were found to be hypermutated: three-quarters of these had the expected high microsatellite instability, usually with hypermethylation and MLH1 silencing, and one-quarter had somatic mismatch-repair gene and polymerase e (POLE) mutations. Excluding the hypermutated cancers, colon and rectum cancers were found to have considerably similar patterns of genomic alteration. Twenty-four genes were significantly mutated, and in addition to the expected APC, TP53, SMAD4, PIK3CA and KRAS mutations, we found frequent mutations in ARID1A, SOX9 and FAM123B. Recurrent copy-number alterations include potentially drug-targetable amplifications of ERBB2 and newly discovered amplification of IGF2. Recurrent chromosomal translocations include the fusion of NAV2 and WNT pathway member TCF7L1. Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.”


This 2012 report from Nature was cited 58 times in current journal articles indexed by Thomson Reuters during May-June 2014. During that two-month period, only one other Medicine paper, aside from reviews, garnered a higher number of citations. (The one non-review paper that surpassed it in bimonthly citations was actually another report from the Cancer Genome Atlas Network, previously featured here as a Hot Paper in Medicine; in the latest count, that paper collected 66 citations.) Prior to the most recent bimonthly count, citations to the report listed above have accrued as follows, as tracked by Essential Science Indicators Hot Papers:


March-April 2014: 57 citations
January-February 2014: 76
November-December 2013: 52
September-October 2013: 50
July-August 2013: 46
May-June 2013: 45
March-April 2013: 36
January-February 2013: 43
November-December 2012: 17
September-October 2012: 6
July-August 2012: 4

Total citations to date: 490


SOURCE: Thomson Reuters Web of Science

The data and citation records included in this report are from Thomson Reuters Web of ScienceTM. Web of ScienceTM is a registered trademark of Thomson Reuters. All rights reserved.