SPECIAL TOPICS
Research front maps are diagrammatic representations of the core papers
comprising each front. They are selected from the current Research Front set
that are relevant to the featured special topic. The title for this Research
Front Map is "EARLY RHEUMATOID ARTHRITIS," containing 17 core papers. Source dates: 1998-June 30,
2008 (third bimonthly period 2008).
Each circle represents a highly cited paper whose bibliographic information
is displayed when the user clicks on the circle. The solid lines between circles
represent the strongest co-citation links for each paper (that is, indicating
that the papers are frequently cited together); weaker links are indicated by
dashed lines. Papers close to each other on the map are generally more highly
co-cited. The most recent paper(s) are indicated in pink. For this particular map, annotations have been added representing the main research themes. These appear as labels attached to specific regions on the maps.
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Core Papers
Label: Weinblatt-2003
Title: Adalimumab, a fully human anti-tumor necrosis factor a monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate - The ARMADA trial
Journal: ARTHRITIS RHEUM, 48 (1): 35-45 JAN 2003
Citations: 419
Authors: Weinblatt, ME;Keystone, EC;Furst, DE;Moreland, LW;Weisman, MH;Birbara, CA;Teoh, LA;Fischkoff, SA;Chartash, EK
Addresses:
Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
Brigham & Womens Hosp, Boston, MA 02115 USA
Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada
Univ Calif Los Angeles, Los Angeles, CA USA
Univ Alabama, Birmingham, AL USA
Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
Univ Massachusetts, Worcester, MA 01605 USA
Abbott Labs, Parsippany, NJ USA
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Label: Klareskog-2004
Title: Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
Journal: LANCET, 363 (9410): 675-681 FEB 28 2004
Citations: 378
Authors: Klareskog, L;van der Heijde, D;de Jager, JP;Gough, A;Kalden, J;Malaise, M;Mola, EM;Pavelka, K;Sany, J;Settas, L;Wajdula, J;Pedersen, R;Fatenejad, S;Sanda, M;TEMPO Study Investigators
Addresses:
Karolinska Inst, Karolinska Hosp, Dept Med, Rheumatol Unit, S-17176 Stockholm, Sweden
Karolinska Inst, Karolinska Hosp, Dept Med, Rheumatol Unit, S-17176 Stockholm, Sweden
Univ Hosp, Dept Rheumatol, Maastricht, Netherlands
Gold Coast Rheumatol, Southport, Qld, Australia
Harrogate Dist Hosp, Dept Rheumatol, Harrogate, England
Univ Erlangen Nurnberg, Dept Med 3, Inst Clin Immunol, Erlangen, Germany
Univ Hosp, Ctr Sart Tilman, Dept Rheumatol, Liege, Belgium
Hosp La Paz, Rheumatol Unit, Madrid, Spain
Inst Rheumatol, Prague, Czech Republic
Hosp Lapeyronie, Rheumatol Unit, Montpellier, France
Univ Thessaloniki, AHEPA Gen Hosp, Dept Rheumatol, GR-54006 Thessaloniki, Greece
Wyeth Res, Collegeville, PA USA
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Label: Genovese-2002
Title: Etanercept versus methotrexate in patients with early rheumatoid arthritis - Two-year radiographic and clinical outcomes
Journal: ARTHRITIS RHEUM, 46 (6): 1443-1450 JUN 2002
Citations: 277
Authors: Genovese, MC;Bathon, JM;Martin, RW;Fleischmann, RM;Tesser, JR;Schiff, MH;Keystone, EC;Wasko, MC;Moreland, LW;Weaver, AL;Markenson, J;Cannon, GW;Spencer-Green, G;Finck, BK
Addresses:
Stanford Univ, Sch Med, Dept Med, Div Rheumatol & Immunol, 1000 Welch Rd,203, Palo Alto, CA 94304 USA
Stanford Univ, Stanford, CA 94305 USA
Johns Hopkins Univ, Baltimore, MD USA
Michigan State Univ, Grand Rapids, MI USA
Radiant Res, Dallas, TX USA
Phoenix Ctr Clin Res, Phoenix, AZ USA
Denver Arthrit Clin, Denver, CO USA
Univ Toronto, Toronto, ON, Canada
Univ Pittsburgh, Ctr Med, Pittsburgh, PA USA
Univ Alabama, Birmingham, AL USA
Arthrit Ctr, Lincoln, NE USA
Hosp Special Surg, New York, NY 10021 USA
Vet Affairs Salt Lake City Hlth Care Syst, Salt Lake City, UT USA
Univ Utah, Salt Lake City, UT USA
Immunex Corp, Seattle, WA USA
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Label: Keystone-2004
Title: Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy - A randomized, placebo-cont
Journal: ARTHRITIS RHEUM, 50 (5): 1400-1411 MAY 2004
Citations: 216
Authors: Keystone, EC;Kavanaugh, AF;Sharp, JT;Tannenbaum, H;Hua, Y;Teoh, LS;Fischkoff, SA;Chartash, EK
Addresses:
Mt Sinai Hosp, Rebecca MacDonald Ctr, 2nd Floor,Room 2-006,60 Murray St, Toronto, ON M5G 1X5, Canada
Univ Toronto, Toronto, ON, Canada
Univ Calif San Diego, San Diego, CA 92103 USA
Univ Washington, Sch Med, Seattle, WA USA
McGill Univ, Montreal, PQ, Canada
Abbott Labs, Parsippany, NJ USA
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Label: Goekoop-Ruiterman-2005
Title: Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study) - A randomized, controlled trial
Journal: ARTHRITIS RHEUM, 52 (11): 3381-3390 NOV 2005
Citations: 174
Authors: Goekoop-Ruiterman, YPM;de Vries-Bouwstra, JK;Allaart, CF;van Zeben, D;Kerstens, PJSM;Hazes, JMW;Zwinderman, AH;Ronday, HK;Han, KH;Westedt, ML;Gerards, AH;van Groenendael, JHLM;Lems, WF;van Krugten, MV;Breedveld, FC;Dijkmans, C
Addresses:
Leiden Univ, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands
Leiden Univ, Med Ctr, NL-2300 RC Leiden, Netherlands
Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands
St Franciscus Gasthuis, Rotterdam, Netherlands
Jan Breemen Inst, Amsterdam, Netherlands
Erasmus Med Ctr, Rotterdam, Netherlands
Acad Med Ctr, Amsterdam, Netherlands
Haga Hosp, The Hague, Netherlands
Med Ctr Rijnmond Zuid, Rotterdam, Netherlands
Bronovo Hosp, The Hague, Netherlands
Vlietland Hosp, Schiedam, Neth Antilles
Franciscus Hosp, Roosendaal, Netherlands
Slotervaart Hosp, Amsterdam, Netherlands
Walcheren Hosp, Vlissingen, Netherlands
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Label: Grigor-2004
Title: Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial
Journal: LANCET, 364 (9430): 263-269 JUL 17 2004
Citations: 172
Authors: Grigor, C;Capell, H;Stirling, A;McMahon, AD;Lock, P;Vallance, R;Kincaid, W;Porter, D
Addresses:
Gartnavel Royal Hosp, Glasgow G12 0YN, Lanark, Scotland
Gartnavel Royal Hosp, Glasgow G12 0YN, Lanark, Scotland
Glasgow Royal Infirm, Ctr Rheumat Dis, Glasgow G4 0SF, Lanark, Scotland
Univ Glasgow, Robertson Ctr Biostat, Dept Stat, Glasgow, Lanark, Scotland
Deloitte & Touche, Glasgow, Lanark, Scotland
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Label: Maini-2004
Title: Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate
Journal: ARTHRITIS RHEUM, 50 (4): 1051-1065 APR 2004
Citations: 152
Authors: Maini, RN;Breedveld, FC;Kalden, JR;Smolen, JS;Furst, D;Weisman, MH;St Clair, EW;Keenan, GF;van der Heijde, D;Marsters, PA;Lipsky, PE;Anti-Tumor Necrosis Factor Trial R
Addresses:
NIAMS Intramural Res Program, NIH, 9000 Rockville Pike,Bldg 10,Room 9N228, Bethesda, MD 20892 USA
NIAMS Intramural Res Program, NIH, Bethesda, MD 20892 USA
Kennedy Inst, London, England
Leiden Univ Hosp, Leiden, Netherlands
Inst Clin Immunol & Rheumatol, Erlangen, Germany
Lainz Hosp, A-1130 Vienna, Austria
Ludwig Boltzmann Inst Rheumatol, A-1130 Vienna, Austria
Virginia Mason Hosp, Seattle, WA USA
Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
Duke Univ Hosp S, Durham, NC USA
Centocor Inc, Malvern, PA USA
Univ Hosp, Maastricht, Netherlands
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Label: Breedveld-2006
Title: The PREMIER study - A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had
Journal: ARTHRITIS RHEUM, 54 (1): 26-37 JAN 2006
Citations: 144
Authors: Breedveld, FC;Weisman, MH;Kavanaugh, AF;Cohen, SB;Pavelka, K;van Vollenhoven, R;Sharp, J;Perez, JL;Spencer-Green, GT;Premier Investigatiors
Addresses:
Leiden Univ, Med Ctr, Dept Rheumatol, Albinusdreef 2,C4-R POB 9600, NL-2300 RC Leiden, Netherlands
Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands
Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
Univ Calif San Diego, Ctr Innovat Therapy, La Jolla, CA 92093 USA
Univ Texas, SW Med Ctr, Dallas, TX 75230 USA
Inst Rheumatol, Prague, Czech Republic
Karolinska Hosp, S-10401 Stockholm, Sweden
Univ Washington, Seattle, WA 98195 USA
Abbott Labs, Parsippany, NJ USA
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Label: Furst-2003
Title: Adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: Results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis)
Journal: J RHEUMATOL, 30 (12): 2563-2571 DEC 2003
Citations: 141
Authors: Furst, DE;Schiff, MH;Fleischmann, RM;Strand, V;Birbara, CA;Compagnone, D;Fischkoff, SA;Chartash, EK
Addresses:
Univ Calif Los Angeles, Rehabil Ctr 32 59, Dept Med, Div Rheumatol, 1000 Vet Ave,Box 951670, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Rehabil Ctr 32 59, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
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Label: Quinn-2005
Title: Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal - Results from a tw
Journal: ARTHRITIS RHEUM, 52 (1): 27-35 JAN 2005
Citations: 113
Authors: Quinn, MA;Conaghan, PG;O'Connor, PJ;Karim, Z;Greenstein, A;Brown, A;Brown, C;Fraser, A;Jarret, S;Emery, P
Addresses:
Leeds Teaching Hosp Trust, Acad Unit Musculoskeletal Dis, Leeds Gen Infirm, 1st Floor,Great George St, Leeds LS1 3EX, W Yorkshire, England
Leeds Gen Infirm, Leeds, W Yorkshire, England
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Label: Smolen-2005
Title: Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement - A detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with c
Journal: ARTHRITIS RHEUM, 52 (4): 1020-1030 APR 2005
Citations: 74
Authors: Smolen, JS;Han, C;Bala, M;Maini, RN;Kalden, JR;van der Heijde, D;Breedveld, FC;Furst, DE;Lipsky, PE;ATTRACT Study Grp
Addresses:
Med Univ Vienna, Div Rheumatol, Dept Internal Med 3, Waehriinger Guertal 18-20, A-1090 Vienna, Austria
Med Univ Vienna, Div Rheumatol, Dept Internal Med 3, A-1090 Vienna, Austria
Lainz Hosp, A-1090 Vienna, Austria
Centocor Inc, Malvern, PA USA
Kennedy Inst, London W6 7DW, England
Univ Erlangen Nurnberg, Erlangen, Germany
Univ Hosp Maastricht, Maastricht, Netherlands
Leiden Univ, Ctr Med, Leiden, Netherlands
Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA
NIH, Bethesda, MD 20892 USA
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Label: Schiff-2006
Title: Safety analyses of adalimumab (HUMIRA) in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritis
Journal: ANN RHEUM DIS, 65 (7): 889-894 JUL 2006
Citations: 56
Authors: Schiff, MH;Burmester, GR;Kent, JD;Pangan, AL;Kupper, H;Fitzpatrick, SB;Donovan, C
Addresses:
Denver Arthrit Clin PC, 200 Spruce St,Suite 100, Denver, CO 80230 USA
Denver Arthrit Clin PC, Denver, CO 80230 USA
Humboldt Univ, Charite, Dept Rheumatol, Berlin, Germany
Abbott Labs, Abbott Pk, IL 60064 USA
Abbott GmbH & Co KG, Immunosci Europe, Ludwigshafen, Germany
Abbott Labs, PostmktSafety Evaluat, Abbott Pk, IL 60064 USA
Abbott Labs, Parsippany, NJ USA
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Label: vanderHeijde-2006
Title: Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis - Two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial
Journal: ARTHRITIS RHEUM, 54 (4): 1063-1074 APR 2006
Citations: 47
Authors: van der Heijde, D;Klareskog, L;Rodriguez-Valverde, V;Codreanu, C;Bolosiu, H;Melo-Gomes, J;Tornero-Molina, J;Wajdula, J;Pedersen, R;Fatenejad, S;TEMPO Study Invest
Addresses:
Univ Hosp Maastrict, Dept Rheumatol, POB 5800, NL-6202 AZ Maastricht, Netherlands
Univ Hosp Maastrict, Dept Rheumatol, NL-6202 AZ Maastricht, Netherlands
Karolinska Inst, Stockholm, Sweden
Univ Cantabria, Hosp Marques Valdecilla, E-39005 Santander, Spain
Cent Methodol Reumatol, Bucharest, Romania
Clin Reumatol, Cluj Napoca, Romania
Inst Portugues Reumatol, Lisbon, Portugal
Univ Guadalajara, Guadalajara, Spain
Wyeth Ayerst Res, Collegeville, PA USA
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Label: Smolen-2006
Title: Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab - Results from the ASPIRE trial
Journal: ARTHRITIS RHEUM, 54 (3): 702-710 MAR 2006
Citations: 46
Authors: Smolen, JS;van der Heijde, DMFM;St Clair, EW;Emery, P;Bathon, JM;Keystone, E;Maini, RN;Kalden, JR;Schiff, M;Baker, D;Han, CL;Han, J;Bala, M;ASPIRE Study Grp
Addresses:
Duke Univ, Med Ctr, Box 3874, Durham, NC 27705 USA
Duke Univ, Med Ctr, Durham, NC 27705 USA
Med Univ Vienna, Vienna, Austria
Lainz Hosp, Vienna, Austria
Univ Maastricht, Maastricht, Netherlands
Univ Leeds, Leeds, W Yorkshire, England
Johns Hopkins Univ, Baltimore, MD USA
Univ Toronto, Toronto, ON, Canada
Kennedy Inst, London, England
Univ Erlangen Nurnberg, Erlangen, Germany
Denver Arthrit Clin, Denver, CO USA
Centocor Inc, Malvern, PA 19355 USA
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Label: Goekoop-Ruiterman-2007
Title: Comparison of treatment strategies in early rheumatoid arthritis - A randomized trial
Journal: ANN INTERN MED, 146 (6): 406-415 MAR 20 2007
Citations: 34
Authors: Goekoop-Ruiterman, YPM;de Vries-Bouwstra, JK;Allaart, CF;van Zeben, D;Kerstens, PJSM;Hazes, JMW;Zwinderman, AH;Peeters, AJ;de Jonge-Bok, JM;Mallee, C;de Beus, WM;de Sonnaville, PBJ;Ewals, JAPM;Breedveld, FC;Dijkmans, BAC
Addresses:
Leiden Univ, Med Ctr, Dept Rheumatol, C1-R,POB 9600, NL-2300 RC Leiden, Netherlands
Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands
Vrije Univ Amsterdam, Med Ctr, Jan Van Breemen Inst, Slotervaart Hosp, Amsterdam, Netherlands
Amsterdam Med Ctr, Amsterdam, Netherlands
Erasmus MC, Rotterdam, Netherlands
Sint Francis Hosp, Rotterdam, Netherlands
Reinier Graaf Gasthuis, Delft, Netherlands
Groene Hart Hosp, Gouda, Netherlands
Kennemer Gasthuis, Haarlem, Netherlands
Med Ctr Haaglanden, Leidschendam, Netherlands
Haga Hosp, The Hague, Netherlands
Oosterschelde Hosp, Goes, Netherlands
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Label: vanDongen-2007
Title: Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis - A double-blind, randomized, placebo-controlled trial
Journal: ARTHRITIS RHEUM, 56 (5): 1424-1432 MAY 2007
Citations: 14
Authors: van Dongen, H;van Aken, J;Lard, LR;Visser, K;Ronday, HK;Hulsmans, HMJ;Speyer, I;Westedt, ML;Peeters, AJ;Allaart, CF;Toes, REM;Breedveld, FC;Huizinga, TWJ
Addresses:
Leiden Univ, Med Ctr, Dept Rheumatol, POB 9600, NL-2300 RC Leiden, Netherlands
Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands
Haga Hosp, The Hague, Netherlands
Bronovo Hosp, The Hague, Netherlands
Reinier de Graaf Hosp, Delft, Netherlands
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Label: Donahue-2008
Title: Systematic review: Comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritis
Journal: ANN INTERN MED, 148 (2): 124-134 JAN 15 2008
Citations: 5
Authors: Donahue, KE;Gartlehner, G;Jonas, DE;Lux, LJ;Thieda, P;Jonas, BL;Hansen, RA;Morgan, LC;Lohr, KN
Addresses:
Univ N Carolina, Dept Family Med, CB 7595,590 Manning Dr, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Family Med, Chapel Hill, NC 27599 USA
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KEYWORDS: ACTIVE RHEUMATOID
ARTHRITIS RECEIVING CONCOMITANT METHOTREXATE THERAPY; RHEUMATOID ARTHRITIS
PATIENTS; EARLY RHEUMATOID ARTHRITIS TREATED; EARLY RHEUMATOID ARTHRITIS (THE;
RHEUMATOID ARTHRITIS (THE TICORA STUDY). 8844.
Special Topics : Rheumatoid Arthritis : EARLY RHEUMATOID ARTHRITIS - Research Front Map
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