AMYLOID BETA PROTEIN

EMERGING RESEARCH FRONTS

Research Front Map - June 2008

This Research Front on AMYLOID BETA PROTEIN from the field of Neurosciences & Behavior was selected for mapping from the list of Emerging Research Fronts for June 2008 (data from the sixth bimonthly period of 2007). The map is a diagrammatic representation of the 13 core papers comprising the front. Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together). Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink.

Core Papers

Label: Walsh-2002
Title: Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
Journal: NATURE, 416 (6880): 535-539 APR 4 2002
Citations: 785
Authors: Walsh, DM;Klyubin, I;Fadeeva, JV;Cullen, WK;Anwyl, R;Wolfe, MS;Rowan, MJ;Selkoe, DJ
Addresses:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
Univ Dublin Trinity Coll, Dept Pharmacol & Therapeut, Dublin 2, Ireland
Univ Dublin Trinity Coll, Dept Physiol, Dublin 2, Ireland

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Label: Bucciantini-2002
Title: Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
Journal: NATURE, 416 (6880): 507-511 APR 4 2002
Citations: 636
Authors: Bucciantini, M;Giannoni, E;Chiti, F;Baroni, F;Formigli, L;Zurdo, JS;Taddei, N;Ramponi, G;Dobson, CM;Stefani, M
Addresses:
Univ Florence, Dipartimento Sci Biochim, Viale Morgagni 50, I-50134 Florence, Italy
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Univ Florence, Dipartimento Anat Istol & Med Legale, I-50134 Florence, Italy
Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

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Label: Kayed-2003
Title: Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Journal: SCIENCE, 300 (5618): 486-489 APR 18 2003
Citations: 629
Authors: Kayed, R;Head, E;Thompson, JL;McIntire, TM;Milton, SC;Cotman, CW;Glabe, CG
Addresses:
Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA
Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

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Label: Lashuel-2002
Title: Neurodegenerative disease - Amyloid pores from pathogenic mutations
Journal: NATURE, 418 (6895): 291-291 JUL 18 2002
Citations: 268
Authors: Lashuel, HA;Hartley, D;Petre, BM;Walz, T;Lansbury, PT
Addresses:
Brigham & Womens Hosp, Ctr Neurol Dis, 65 Landsdowne St, Cambridge, MA 02139 USA
Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Dept Neurol, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

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Label: Dahlgren-2002
Title: Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability
Journal: J BIOL CHEM, 277 (35): 32046-32053 AUG 30 2002
Citations: 216
Authors: Dahlgren, KN;Manelli, AM;Stine, WB;Baker, LK;Krafft, GA;LaDu, MJ
Addresses:
Evanston NW Healthcare Res Inst, Dept Med, 1801 Maple Ave,Suite 6240, Evanston, IL 60201 USA
Evanston NW Healthcare Res Inst, Dept Med, Evanston, IL 60201 USA
Evanston NW Healthcare Res Inst, Dept Neurol, Evanston, IL 60201 USA
Northwestern Univ, Alzheimers Dis Core Ctr, Chicago, IL 60611 USA
Northwestern Univ, Dept Mol Pharmacol, Chicago, IL 60611 USA
Northwestern Univ, Dept Neurobiol & Physiol, Chicago, IL 60611 USA

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Label: Gong-2003
Title: Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
Journal: PROC NAT ACAD SCI USA, 100 (18): 10417-10422 SEP 2 2003
Citations: 214
Authors: Gong, YS;Chang, L;Viola, KL;Lacor, PN;Lambert, MP;Finch, CE;Krafft, GA;Klein, WL
Addresses:
Northwestern Univ, Dept Neurobiol & Physiol, 2153 Sheridan Rd, Evanston, IL 60208 USA
Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA
Univ So Calif, Andrus Gerontol Ctr, Los Angeles, CA 90089 USA
Acumen Pharmaceut, Glenview, IL 60025 USA

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Label: Cleary-2005
Title: Natural oligomers of the amyloid-protein specifically disrupt cognitive function
Journal: NAT NEUROSCI, 8 (1): 79-84 JAN 2005
Citations: 206
Authors: Cleary, JP;Walsh, DM;Hofmeister, JJ;Shankar, GM;Kuskowski, MA;Selkoe, DJ;Ashe, KH
Addresses:
Minneapolis Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Minneapolis, MN 55417 USA
Minneapolis Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Minneapolis, MN 55417 USA
Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
Univ Coll Dublin, Conway Inst Biomed & Biomol Res, Lab Neurodegenerat Res, Dublin 4, Ireland
Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA

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Label: Lesne-2006
Title: A specific amyloid-beta protein assembly in the brain impairs memory
Journal: NATURE, 440 (7082): 352-357 MAR 16 2006
Citations: 193
Authors: Lesne, S;Koh, MT;Kotilinek, L;Kayed, R;Glabe, CG;Yang, A;Gallagher, M;Ashe, KH
Addresses:
Univ Minnesota, Sch Med, Dept Neurol, Minneapolis, MN 55455 USA
Univ Minnesota, Sch Med, Dept Neurol, Minneapolis, MN 55455 USA
Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA
Univ Minnesota, Sch Med, Grad Program Neurosci, Minneapolis, MN 55455 USA
Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA
Minneapolis VA Med Ctr, Ctr Geriatr Res Educ & Clin, Minneapolis, MN 55417 USA
Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
Univ So Calif, Dept Pharmaceut Sci, Los Angeles, CA 90089 USA

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Label: Stine-2003
Title: In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis
Journal: J BIOL CHEM, 278 (13): 11612-11622 MAR 28 2003
Citations: 121
Authors: Stine, WB;Dahlgren, KN;Krafft, GA;LaDu, MJ
Addresses:
Evanston NW Healthcare Res Inst, Dept Med, Div Geriatr, 1801 Maple Ave,Suite 6240, Evanston, IL 60201 USA
Evanston NW Healthcare Res Inst, Dept Med, Div Geriatr, Evanston, IL 60201 USA
Northwestern Univ, Dept Mol Pharmacol, Chicago, IL 60611 USA
Northwestern Univ, Dept Neurobiol & Physiol, Chicago, IL 60611 USA
Northwestern Univ, Alzheimers Dis Core Ctr, Chicago, IL 60611 USA

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Label: Chromy-2003
Title: Self-assembly of A beta(1-42) into globular neurotoxins
Journal: BIOCHEMISTRY-USA, 42 (44): 12749-12760 NOV 11 2003
Citations: 112
Authors: Chromy, BA;Nowak, RJ;Lambert, MP;Viola, KL;Chang, L;Velasco, PT;Jones, BW;Fernandez, SJ;Lacor, PN;Horowitz, P;Finch, CE;Krafft, GA;Klein, WL
Addresses:
Northwestern Univ, Dept Neurobiol & Physiol, 2205 Tech Dr, Evanston, IL 60208 USA
Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA
Lawrence Livermore Natl Lab, Biodef Div, Biol & Biotechnol Res Program, Livermore, CA 94551 USA
Harvard Univ, Sch Med, Dept Neurol, Cambridge, MA 02139 USA
Northwestern Univ, Sch Med, Chicago, IL 60611 USA
Univ So Calif, Andrus Gerontol Ctr, Los Angeles, CA 90089 USA
Acumen Pharmaceut, Glenview, IL 60025 USA

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Label: Lacor-2004
Title: Synaptic targeting by Alzheimer's-related amyloid beta oligomers
Journal: J NEUROSCI, 24 (45): 10191-10200 NOV 10 2004
Citations: 101
Authors: Lacor, PN;Buniel, MC;Chang, L;Fernandez, SJ;Gong, YS;Viola, KL;Lambert, MP;Velasco, PT;Bigio, EH;Finch, CE;Krafft, GA;Klein, WL
Addresses:
Northwestern Univ, Dept Neurobiol & Physiol, OT Hogan Biol Sci 5-110,2205 Tech Dr, Evanston, IL 60208 USA
Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA
Northwestern Feinberg Sch Med, Northwestern Alzheimers Dis Ctr, Chicago, IL 60611 USA
Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA
Acumen Pharmaceut, Glenview, IL 60025 USA

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Label: Klyubin-2005
Title: Amyloid beta protein immunotherapy neutralizes A beta oligomers that disrupt synaptic plasticity in vivo
Journal: NATURE MED, 11 (5): 556-561 MAY 2005
Citations: 86
Authors: Klyubin, I;Walsh, DM;Lemere, CA;Cullen, WK;Shankar, GM;Betts, V;Spooner, ET;Jiang, LY;Anwyl, R;Selkoe, DJ;Rowan, MJ
Addresses:
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Univ Dublin Trinity Coll, Inst Neurosci, Dublin 2, Ireland
Univ Dublin Trinity Coll, Dept Pharmacol & Therapeut, Dublin 2, Ireland
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
Natl Univ Ireland Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland
Univ Dublin Trinity Coll, Dept Physiol, Dublin 2, Ireland

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Label: Townsend-2006
Title: Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers
Journal: J PHYSIOL-LONDON, 572 (2): 477-492 APR 15 2006
Citations: 38
Authors: Townsend, M;Shankar, GM;Mehta, T;Walsh, DM;Selkoe, DJ
Addresses:
Harvard Inst Med, Ctr Neurol Dis, 77 Ave Louis Pasteur,Room 730, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
Univ Coll Dublin, Conway Inst Biomed & Biomol Res, Lab Neurodegenerat Res, Dublin 4, Ireland

Keywords: AMYLOID BETA PROTEIN POTENTLY INHIBIT HIPPOCAMPAL LONG-TERM POTENTIATION IN-VIVO; SOLUBLE AMYLOID OLIGOMERS IMPLIES COMMON MECHANISM; AMYLOID BETA PROTEIN IMMUNOTHERAPY NEUTRALIZES; BETA OLIGOMERS; DISRUPT SYNAPTIC PLASTICITY IN-VIVO.

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Emerging Research Fronts : Maps : AMYLOID BETA PROTEIN - Research Front Map